The members of this family are also known as herpesviruses. (to creep), referring to the latent, recurring infections typical of this group of viruses. Human herpes viruses have been treated as an exception (human rather than hominid). There are eight currently identified members of the human herpes virus family. Beta-herpesviruses: CMV, HHV-6 and HHV-7 – these have long reproductive cycles and a restricted host range. Between reactivations, the virus is truly latent – viral DNA is maintained as an episome (not integrated) with limited expression of specific virus genes required for the maintenance of latency. EMIS Group plc. They are known as the human herpesviruses and are herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus 6, human herpesvirus 7 and, most recently, Kaposi’s Sarcoma herpesvirus. Secondly, the synthesis and assembly of viral DNA is initiated in the nucleus. Finally, all herpesviruses establish latent infection within tissues that are characteristic for each virus, reflecting the unique tissue trophism of each member of this family. For group E viral genomes, such as herpes simplex virus and cytomegalovirus, the genomes are divided into internal unique sequences whereby both termini are repeated in an inverted orientation.
Members of the family Herpesviridae replicate their genomes in the infected cell nucleus and have a characteristic virion morphology, which consists of the envelope, tegument, capsid and core (Davison and Clements, 1997). Herpesvirus genomes consist of linear, double-stranded DNA molecules that range in size from about 125 to 240kbp and in nucleotide composition from 32 to 75 G+C, depending on the virus species (Honess, 1984). Local CG suppression of the major immediate early gene locus of HCMV has also been noted (Honess et al. Three major groups of viruses possess the herpesvirus morphology, including closely similar capsid structures, but share very little genetic similarity (Davison, 1992; Booy et al. Any member of a unique class of infectious agents, which were originally distinguished by their smallness (hence, they were described as filtrable because of their ability to pass through fine ceramic filters that blocked all cells, including bacteria) and their inability to replicate outside of and without assistance of a living host cell. Within the host cell the genetic material of a DNA virus is replicated and transcribed into messenger RNA by host cell enzymes, and proteins coded for by viral genes are synthesized by host cell ribosomes. Influenza virus any of a group of orthomyxoviruses that cause influenza; there are at least three serotypes or species (A, B, and C). Varicella-zoster virus former name for human herpesvirus 3; see herpesvirus. Herpes viruses cause a wide range of latent, recurring infections including oral and genital herpes, cytomegalovirus, and chicken pox. Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans. The family name is derived from the Greek word herpein ( to creep ), referring to the latent, recurring infections typical of this group of viruses.
Viruses that induce cellular DNA damage include members of the herpes virus group, adenovirus, mumps-virus, measles-virus, rubella-virus, poliovirus, and papilloma-virus (reviewed in Fortunato et al. CMV is a member of the herpesvirus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (that can cause infectious mononucleosis). Once a person has had a CMV infection, the virus usually lies dormant (or inactive) in the body, but it can be reactivated. Special viral DNA-detecting tests are also sometimes used to diagnosis CMV infection. These viruses contain DNA surrounded by a lipid envelope. Among members of this group, this virus is most closely related to cytomegalovirus (CMV) and HHV-7.
Comparative Analysis Of The Genomes
Cytomegalovirus, human herpesvirus 5, Vertebrates. Herpesviridae is a family of DNA viruses that infect humans and other animals. They are the herpes simplex virus 1, herpes simplex virus 2, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, Human herpesvirus-6, Human herpesvirus-7, and Kaposi s sarcoma herpes virus. Although members of the Herpesviridae family differ with respect to the clinical manifestations of the diseases they cause, they generally have a global distribution and are highly disseminated in nature. Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the Herpesviridae family. The other family members include herpes simplex virus type 1 (HSV-1 or HHV-1) and herpes simplex virus type 2 (HSV-2 or HHV-2), varicella zoster virus (VZV), human herpes virus (HHV) 6, HHV-7, and HHV-8. Eight human herpes viruses have been identified to date (Table 1), and are assigned to three subfamilies, the alpha- beta- and gamma-herpesvirinae, on the basis of shared genomic and biological properties. Vaccination against human cytomegalovirus (HCMV). RNA viruses occur in four distinct groups: Those with a genome that consists of single-stranded antisense RNA; that is, RNA that is the complement of the message sense. Also called human herpesvirus 8 (HHV-8). human cytomegalovirus (HCMV); most of us have it; can cause blindness even death in people with suppressed immune systems. Utility of a Multiplex PCR Assay for Detecting Herpesvirus DNA in Clinical Samples. A multiplex PCR was designed to amplify herpes simplex virus types 1 and 2, cytomegalovirus, and varicella-zoster virus DNA present in a diverse range of clinical material. Detection of members of this group may comprise up to half the workload of many diagnostic virology laboratories.