This patient also had positive result on polymerase chain reaction assay for herpes simplex virus, which is both sensitive and specific. In children older than 3 months and in adults, HSE is usually localized to the temporal and frontal lobes and is caused by HSV-1. Causes. Herpes simplex encephalitis is a complication of infection with the herpes simplex virus. In most cases, the disorder results from herpes simplex virus type I (HSV-I). Herpes viruses are the other major cause of encephalitis in the U.S. This virus family includes herpes simplex, Epstein-Barr, cytomegalovirus, and varicella-zoster.
Management of herpes simplex encephalitis (HSE) has been considerably improved by the availability of acyclovir therapy and rapid polymerase chain reaction (PCR) based diagnostic assays. Second, herpes simplex virus (HSV) DNA amplification by PCR analysis of CSF has been the reference standard for early diagnosis of HSE since the early 1990s 5 7, thus greatly improving early therapeutic decisions 8, 9. The delay between the onset of symptoms and initiation of treatment, the delay between hospital admission and initiation of acyclovir, the dose and duration of antiviral treatment, and the use of drugs to reduce cerebral edema and/or to control seizures were recorded. Case Report from JAMA Neurology Atypical Brainstem Encephalitis Caused by Herpes Simplex Virus 2. RESULTS A diagnosis of herpes simplex encephalitis was confirmed in 42 patients. All but one of the 34 surviving patients had neurological symptoms, an abnormal neurological examination, or both. Herpes simplex virus DNA was found in the first CSF specimen in all of the 36 patients in which this test was used.
Effect of Antiviral Therapy on Herpes Simplex Virus (HSV) Deoxyribonucleic Acid (DNA) in Cerebral Spinal Fluid (CSF) Time Frame: Day 0 and Day 90. Herpes simplex encephalitis (HSE) remains the most common cause of sporadic fatal encephalitis in the world. We describe a 53-year-old man with herpes simplex virus (HSV) brainstem encephalitis diagnosed based by positive HSV immunoglobulin M antibodies from cerebrospinal fluid. Encephalitis is usually caused by a virus, but other things (including bacteria) can also cause it.
Outcome Of And Prognostic Factors For Herpes Simplex Encephalitis In Adult Patients: Results Of A Multicenter Study
Nevertheless, early diagnosis of HSV encephalitis and its long-term management continue to challenge practitioners, primarily because of the paucity of clinical symptoms and laboratory abnormalities associated with early disease. Herpes simplex encephalitis – common form of acute encephalitis caused by herpes simplex 1; usually affects the temporal and frontal lobes acute. Cephalitis, encephalitis, phrenitis – inflammation of the brain usually caused by a virus;